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Frank Friedlos Selected Research

gamma-Glutamyl Hydrolase (Carboxypeptidase G2)

7/2008Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
5/2007Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.
6/2005Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.
3/2002Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.

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Frank Friedlos Research Topics

Disease

12Neoplasms (Cancer)
09/2010 - 03/2002
8Melanoma (Melanoma, Malignant)
09/2010 - 08/2004
4Carcinoma (Carcinomatosis)
07/2008 - 03/2002
3Sarcoma (Soft Tissue Sarcoma)
09/2010 - 06/2008
2Breast Neoplasms (Breast Cancer)
08/2005 - 03/2002
1Hepatocellular Carcinoma (Hepatoma)
06/2005

Drug/Important Bio-Agent (IBA)

6ProdrugsIBA
06/2009 - 03/2002
6EnzymesIBA
06/2009 - 03/2002
4gamma-Glutamyl Hydrolase (Carboxypeptidase G2)IBA
07/2008 - 03/2002
3Threonine (L-Threonine)FDA Link
09/2010 - 08/2004
3Phosphotransferases (Kinase)IBA
09/2010 - 12/2005
3Protein Kinases (Protein Kinase)IBA
09/2010 - 08/2004
3Serine (L-Serine)FDA Link
09/2010 - 08/2004
3Pharmaceutical PreparationsIBA
06/2009 - 06/2005
3Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
04/2009 - 01/2006
2Telomerase (Telomerase Reverse Transcriptase)IBA
05/2007 - 06/2005
2Glutamic Acid (Glutamate)FDA Link
08/2005 - 03/2002
2beta-Galactosidase (Lactaid)IBA
04/2003 - 03/2002
1pyrazoleIBA
09/2010
1Proto-Oncogene Proteins B-rafIBA
07/2009
1imidazoloneIBA
04/2009
1VNP 20009 (VNP20009)IBA
07/2008
1PyrazinesIBA
06/2008
1ZD 2767IBA
05/2007
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
12/2005
1tanespimycin (17AAG)IBA
12/2005
1DNA (Deoxyribonucleic Acid)IBA
08/2004
14- ((2- chloroethyl)(2- mesyloxyethyl)amino)benzoylglutamic acid (CMDA)IBA
03/2002
1glutamate carboxypeptidaseIBA
03/2002

Therapy/Procedure

3Therapeutics
06/2009 - 06/2005